Alzheimer's disease

Aim: to know cellular basis of CNS disease

Suggested reading:

Overview

Books

Alzheimer's diseaseCitron M (2004) b-Secretase inhibition for the treatment of Alzheimer's disease – promise and challenge Trends Pharm Sci 25:92-97

Verdile G et al (2004) The role of beta amyloid in Alzheimer’s disease: still a cause of everything or the only one who got caught?   Pharmacological Research 50:397-409  

Goedert, M & Spillantini, MG (2006) A Century of Alzheimer's Disease Science 314:777 - 781  

Roberson, ED & Mucke, L (2006) 100 Years and Counting: Prospects for Defeating Alzheimer's Disease Science, 314:781 - 784

Hardy, J (2006) A Hundred Years of Alzheimer's Disease Research Neuron 52:3-13

LaFerla F et al (2007) Intracellular amyloid-bold beta in Alzheimer's disease Nature rev neurosci 8, 499-509

Ballatore, C (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Nature Reviews Neuroscience 8, 663-672

St George-Hyslop, PH & Morris, JC (2008) Will anti-amyloid therapies work for Alzheimer's disease? 
Lancet 372:180-182

Wozniak, MA (2008) Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques J pathol 217:131 - 138

Vassar R et al (2009)  The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential  J neurosci 29:12787-12794

Biran Y  et al (2009) Pharmacotherapeutic targets in Alzheimer's disease J Cell Mol Med 13: 61-68

Zatta P (2009) Alzheimer’s disease, metal ions and metal homeostatic therapy Trends pharm Sci 30:346-355

Bu, G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Nature Revi Neurosci 10, 333-344

Carter, MD (2010) The Development of New Therapeutics for Alzheimer's Disease Clinical Pharmacology & Therapeutics 88: 475–486

Web Links

Search for BBC history of the NICE Alzheimer's drugs review in the courts

http://www.dailymail.co.uk/health/article-1039677/Daily-pill-halts-Alzheimers-hailed-biggest-breakthrough-disease-100-years.html
See commentary at http://pipeline.corante.com/archives/2008/07/31/rember_for_alzheimers_methylene_blues_comeback.php

http://news.bbc.co.uk/1/hi/health/7770680.stm

Powerpoint

The powerpoint presentation (for york.ac.uk computers) is here

page last updated by Chris Elliott, December 7, 2010